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Copyright

Aswin Sai Narain Seshasayee

Published On

2025-02-28

Page Range

pp. 107–160

Language

  • English

Print Length

54 pages

4. The ebb and flow of bacterial genomes

Chapter of: Bacterial Genomes: Trees and Networks(pp. 107–160)
The evolution of bacterial genomes is driven by gene loss, as represented by the genomes of endosymbionts and various other lineages. This is compensated in many genomes by gene gain by horizontal gene transfer, the phenomenon by which bacteria gain chunks of DNA and new functions, not from their parents, but from other species. These processes occur over processes of mutation, which can often be non-random in type, rates and location on genomes, together shaping genomes under the influence of selection.

Contributors

Aswin Sai Narain Seshasayee

(author)
Researcher and Associate Professor at National Centre for Biological Sciences

Aswin Sai Narain Seshasayee is a researcher and Associate Professor at the National Centre for Biological Sciences (NCBS), a centre of Tata Institute of Fundamental Research (TIFR) in Bangalore, India. His lab is interested in fundamental aspects of the function and evolution of bacterial genomes and gene regulatory networks. His career in the sciences started off with a Bachelors of Technology at Anna University, Chennai, India, during which a lot of time left alone to explore and break things in the bioinformatics laboratory of Professor Gautam Pennathur and in the experimental microbiology and protein engineering laboratory of Professor Sankaran encouraged him to take up research for a career. He then pursued research as an intern, a PhD student and then briefly a postdoc with Nicholas Luscombe at EMBL-European Bioinformatics Institute, Hinxton, Cambridge, UK (and St John’s College and Girton College, University of Cambridge). He has been with NCBS since December 2010, his research here funded over the years by the Department of Atomic Energy (Govt of India) core support to TIFR and NCBS, Department of Biotechnology, Department of Science and Technology and Science and Engineering Research Board (all Govt of India), CEFIPRA and DBT-Wellcome Trust India Alliance. Beyond science, he enjoys making music, painting watercolour landscapes and reading classic crime and fantasy fiction and popular history.